Manovikas Biomedical Research and Diagnostic Centre (MBRDC)
Manovikas Biomedical Research and Diagnostic Centre (BRDC) is the research wing of Manovikas Kendra, inaugurated in August 2000 by Dr. Manju Sharma, the then Secretary, Department of Biotechnology, Ministry of Science and Technology, Govt of India. The Centre has been recognized as a Scientific and Industrial Research Organization by the Department of Scientific and Industrial Research, Govt of India. The Centre deals with the genetic basis of neurodevelopment disorders, especially those which present unique opportunities for understanding gene-behaviour related relationships and distinct aspects of cognitive/socialemotional phenotypes.
Nothing has such power to broaden the mind as the ability to investigate systematically and truly all that comes under thy observation in life (Marcus Aurelius)
Remediation Through EEG-Based Neurofeedback Training
The electroencephalogram-based training to improve performance been proved to be useful in giving relief
to anxiety and hyperactivity/inattention in probands with neurodevelopmental disorders, viz. Down syndrome,
ADHD and ASD.
| Target Group | Abnormality | Consequences | Remediation through |
| ASD | Serotonin deficiency
Neurotransmitter deficiency Vitamin B6 deficiency |
Behavioural problem
Higher disease seerity Several problems including low intelligence |
Pharmacotherapy
Pharmacotherapy Dietary supplementation |
| ADHD | Dopamine deficiency
Vitamin B12 deficiency Increased homocysteine |
Mental & behavioural problem
Several problems including low intelligence Low intelligence |
Pharmacotherapy
Dietary supplementation Dietary supplementation |
| Intellectual disability (ID) | Genetic variants
Increased homocysteine |
Therapeutic success
Low intelligence Chromosomal abnormality |
Pharmacotherapy
Dietary supplementation |
| Down syndrome (DS) | Thyroid deficiency
Folate deficiency |
Mental & behavioural problem
One of the reasons for chromosomal abnormality |
Thyroxin supplementation
Dietary supplementation |
Basic Research Carried Out to Provide Benefit to the Donors & Participants
- Attention Deficit Hyperactivity Disorder (ADHD)
- We have identified role of gene variants in ADHD associated cognitive deficit which would be helpful in targeted therapeutic intervention.
- Genetic analysis indicated influence of inattention but not IQ in executive dysfunction of ADHD probands Analysis of dopaminergic gene variants frequently detected in subjects with ADHD revealed their contribution in drug addiction as well indicating the importance of early intervention in this group of patients.
- Autism Spectrum Disorder
We have detected influence of neurotransmitters like dopamine and serotonin in the behavioral attributes, which is modified further by gender of the affected subject.
Our ongoing studies have also helped in understanding the downstream pathways of neurotransmitters, chemicals governing different brain functions. - Down’s syndrome‐ Nutritional factors were found to have major contribution in trisomy 21.
National Support Received for Manpower Development
Adhoc research grant from the Indian Council of Medical Research 2021-2024 (Number: 5/4-4/165/M/2020-NCD-11)
List of few recent publications in International Peer Reviewed Journals
- Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1 deficiency were detected in the Indian ADHD probands. (2022). Chatterjee M, Saha S, Dutta N, Sinha S, Mukhopadhyay K. Scientific Reports, 12(1), 18449. doi:10.1038/s41598-022-21948-0
- Post-treatment symptomatic improvement of the eastern Indian ADHD probands is influenced by CYP2D6genetic variations. (2022). Chatterjee M, Saha S, Maitra S, Ray A, Sinha S, Mukhopadhyay K. Drug Metabolism and Personalized Therapy. doi:10.1515/dmpt-2022-0120.
- A three-pronged analysis confirms the association of the serotoninergic system with attention deficit hyperactivity disorder. (2022). Chatterjee M, Saha S, Sinha S, Mukhopadhyay K. World Journal of Pediatrics. 18(12):825-834. doi:10.1007/s12519-022-00614-5.
- Differential effect of folate metabolic system genetic variants on attention deficit hyperactivity disorder severity. (2022). Saha T, Saha S, Karmakar A, Chatterjee M, Maitra S, Sinha S, Mukhopadhyay K. Human Gene. 34. 10.1016/j.humgen.2022.201096
- GABA Receptor SNPs and Elevated Plasma GABA Levels Affect the Severity of the Indian ASD Probands. (2022). Saha S, Chatterjee M, Dutta N, Sinha S, Mukhopadhyay K. Journal of Molecular Neuroscience.72(6), 1300–1312. doi:10.1007/s12031-022-02023-9
- Analysis of association between components of the folate metabolic pathway and autism spectrum disorder in eastern Indian subjects. (2022). Saha S, Saha T, Rajamma U, Sinha S, Mukhopadhyay K. Molecular biology reports, 49(2), 1281–1293. doi:10.1007/s11033-021-06956-z
- Functional SLC6A3 polymorphisms differentially affect autism spectrum disorder severity: a study on Indian subjects. (2022) Saha S, Chatterjee M, Shom S, Sinha S, Mukhopadhyay K. Metabolic brain disease, 37(2), 397–410. doi:10.1007/s11011-021-00876-4
- Specific dopaminergic genetic variants influence impulsivity, cognitive deficit, and disease severity of Indian ADHD probands. (2022). Maitra S, Chatterjee M, Roychowdhury A, Panda CK, Sinha S, Mukhopadhyay K. Molecular biology reports, 49(8), 7315–7325. doi:10.1007/s11033-022-07521-y
- Birth related parameters are important contributors in autism spectrum disorders. (2022). Banerjee N, Adak P. Scientific reports, 12(1), 14277. doi:10.1038/s41598-022-18628-4
- DNA methylation signatures in autism spectrum disorders. (2021). Banerjee N, Adak P. Nucleus64, 359–372. doi:10.1007/s13237-021-00370-3
Honors Received for Scientific Presentations
- Down Syndrome associated Trisomy 21: Altered epigenetic regulation by folate system gene variants could be one of the reasons. Chatterjee M, Saha T, Maitra S, Sinha S, Mukhopadhyay K. NATCONPH2020: National Conference on “EMERGING TRENDS IN MODERN HEALTH SCIENCES”.School of Health Sciences, NSHM Knowledge Campus, Kolkata. 28-29th February, 2020 –Best Presenter
- Association of GABRQ rs3810651 with severity of Autism Spectrum Disorder in Indo-Caucasoid subjects. Saha S, Chatterjee M, Sinha S, Mukhopadhyay K. NATCONPH2020: National Conference on “EMERGING TRENDS IN MODERN HEALTH SCIENCES”.School of Health Sciences, NSHM Knowledge Campus, Kolkata. 28-29th February, 2020–Best Presenter
- Gamma-aminobutyric acid type A receptor variants are key players in autism spectrum disorders. Adak P, Sinha S, Banerjee N. 19th All India Congress of Genetics and Genomics. CSIR-Indian Institute of Chemical Biology, Kolkata. December 2-4, 2019–Best Presenter.
Collaboration with other Organizations
- CSIR- IICB, Kolkata , India- Active Memorandum of Understanding for basic research
- University of Calcutta, Kolkata, India- Every year M.Sc students from the departments of Bio chemistry and Neuroscience obtain hands-on training at Manovikas Kendra.
Names of the students who worked for Ph.D degree (University of Calcutta) under the guidance of
| Dr. K Mukhopadhyay | Dr. Usha Rajamma | Dr. K. Nandagopal |
| Nipa Bhaduri | Shruti Dutta | Emili Banerjee |
| Samikshan Dutta | Subharngshu Guhathakurta | Disha Banerjee |
| Manali Das | Barsha Sen | Debarati Ghosh |
| Aneek DasBhowmik | AsemSurindra Singh | |
| Arpita Chatterjee | Preeti Jaiswal | |
| Kanyakumarika Sarkar | Deepak Verma | |
| Paramita Ghosh | Barnali Chakraborty | |
| Arpita Dey | ||
| Subhamita Maitra | ||
| Tanusree Saha | ||
| Arijit Karmakar |
