Manovikas Biomedical Research and Diagnostic Centre (MBRDC)

Manovikas Biomedical Research and Diagnostic Centre (BRDC) is the research wing of Manovikas Kendra, inaugurated in August 2000 by Dr. Manju Sharma, the then Secretary, Department of Biotechnology, Ministry of Science and Technology, Govt of India. The Centre has been recognized as a Scientific and Industrial Research Organization by the Department of Scientific and Industrial Research, Govt of India. The Centre deals with the genetic basis of neurodevelopment disorders, especially those which present unique opportunities for understanding gene-behaviour related relationships and distinct aspects of cognitive/socialemotional phenotypes.

Dr. Kanchan Mukhopadhyay

Director, MBRDC

Phone: 033-40019179
Email:

Nothing has such power to broaden the mind as the ability to investigate systematically and truly all that comes under thy observation in life (Marcus Aurelius)

Regular Services Provided

For different neurobehavioral disorders, individualised therapy is provided as detailed below:

 

Target Group Abnormality Consequences Remediation through
ASD Serotonin deficiency

Neurotransmitter deficiency

Vitamin B6 deficiency

Behavioural problem

Higher disease seerity

Several problems including low intelligence

Pharmacotherapy

Pharmacotherapy

Dietary supplementation

ADHD Dopamine deficiency

Vitamin B12 deficiency

Increased homocysteine

Mental & behavioural problem

Several problems including low intelligence

Low intelligence

Pharmacotherapy

Dietary supplementation

Dietary supplementation

Intellectual disability (ID) Genetic variants

Increased homocysteine

Therapeutic success

Low intelligence

Chromosomal abnormality

Pharmacotherapy

Dietary supplementation

Down syndrome (DS) Thyroid deficiency

Folate deficiency

Mental & behavioural problem

One of the reasons for chromosomal abnormality

Thyroxin supplementation

Dietary supplementation

N.B. Each patient is assessed using structured questionnaire and the intervention is recommended by the Clinician based on the test reports.

Remediation Through EEG-Based Neurofeedback Training

The electroencephalogram-based training to improve performance been proved to be useful in giving relief
to anxiety and hyperactivity/inattention in probands with neurodevelopmental disorders, viz. Down syndrome,
ADHD and ASD.

Basic Research Carried Out to Provide Benefit to the Donors & Participants

  • Attention Deficit Hyperactivity Disorder (ADHD)
  • We have identified role of gene variants in ADHD associated cognitive deficit which would be helpful in targeted therapeutic intervention.
  • Genetic analysis indicated influence of inattention but not IQ in executive dysfunction of ADHD probands Analysis of dopaminergic gene variants frequently detected in subjects with ADHD revealed their contribution in drug addiction as well indicating the importance of early intervention in this group of patients.
  • Autism Spectrum Disorder
    We have detected influence of neurotransmitters like dopamine and serotonin in the behavioral attributes, which is modified further by gender of the affected subject.
    Our ongoing studies have also helped in understanding the downstream pathways of neurotransmitters, chemicals governing different brain functions.
  • Down’s syndrome‐ Nutritional factors were found to have major contribution in trisomy 21.

National Support Received for Manpower Development

Ms. Barnali Chakraborty – ICMR Senior Research Fellow (16/07/14-15/07/18



Articles Published in International Peer Reviewed Journals

  • Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo- Caucasoid Attention Deficit Hyperactivity Disorder probands. Chatterjee M, Saha S, Shom  S, Sinha S, Mukhopadhyay K. Molecular Biology Reports, 48(4):3213- 3222, 2021. doi :10.1007/s11033-021- 06365-2.
  • A pioneering study indicate role of GABRQ rs3810651 in ASD severity of Indo- Caucasoid female probands. S Saha, M Chatterjee, S Sinha & K Mukhopadhyay. Scientific Reports 11 , 7010 , 2021. doi.org/10.1038/s41598-021-86496-5.
  • Association of Dopamine Transporter Gene with Heroin Dependence in an Indian Subpopulation from Manipur. Koijam A S, Hijam AC, Singh AS ,  Jaiswal P , Mukhopadhyay K, Rajamma U, Haobam R. Journal of Molecular Neuroscience, 71, 122–136, 2021. doi.org /10.1007/s12031- 020-01633-5.
  • An Association Study of Gamma – Aminobutyric Acid Type A Receptor Variants and Susceptibility to Autism Spectrum Disorders. Adak P, Sinha S, Banerjee N. Journal  of Autism & Developmental Disorders. 2021 (Online first) doi: 10.1007/s10803-020-04865-x.
  • Working memory, impulsivity and emotional regulation correlates with frontal asymmetry of healthy young subjects during auditory session. Maitra S, Chatterjee M, Sinha S, Mukhopadhyay K. Neural Network World, 6: 367-378, 2020. doi.org/10.14311/nnw.2020.30.024
  • Autistic traits and components of the folate metabolic system: An explorative analysis in the eastern Indian ASD subjects. Saha S, Saha T , Sinha S , Rajamma U , Mukhopadhyay K . Nutritional Neuroscience, 23(11), 860-867, 2020. doi.org/10.1080/1028415X.2019.1570442.
  • A single nucleotide polymorphism in OPRM1 (rs483481) and risk for heroin use disorder. Koijam AS, Chakraborty B, Mukhopadhyay K, Rajamma U, Haobam R. Journal of Addictive Diseases, 38:2, 214- 222, 2020. doi.org/10.1080/ 10550887. 2020.1740070.
  • Folate system gene variant rs1801394 66A>G may have a causal role in Down’s syndrome in the eastern Indian population. Chatterjee M, Saha T, Maitra S, Sinha S, Mukhopadhyay K. International J of Molecular & Cellular Medicine. 9:3, 2020.

Presentation

  • Positive association of MAOA and VMAT2 with Autism Spectrum Disorder (ASD) in the Indian population. Chakraborti B, Verma D, Sinha S, Mohanakumar KP, Mukhopadhyay K, Rajamma U. 25th ISN-APSN Joint Biennial Meeting in conjunction with ANS at Cairns, Australia. 23rd August-27th August. Poster No. MTU02-02.
  • Gender specific distribution of thyroid stimulating hormone receptor gene variants in subjects with Down syndrome. Dey A, Maity A, Sinha S, Mukhopadhyay K. 25th ISN-APSN Joint Biennial Meeting in rd th conjunction with ANS at Cairns, Australia. 23 August-27 August. Poster No. MTU02-04.
  • A possible modifying role of serotonin transporter gene (SLC6A4) polymorphisms on platelet 5-HT levelsand behavioral phenotypic expression of autism. Jaiswal P, Guhathakurta S, Singh AS, Verma D , Sinha S, Mohanakumar KP, Rajamma U. 25th ISN-APSN Joint Biennial Meeting in conjunction with ANS at Cairns, Australia. 23 August-27 August. Poster No. MTU02-08.
  • A pilot study on the eastern Indian ADHD probands to explore role of CDK 5 in the disease etiology. Maitra S, Chatterjee M, Sinha S, Mukhopadhyay K. 25th ISN-APSN Joint Biennial Meeting in conjunction with ANS at Cairns, Australia. 23rd August-27th August. Poster No. MTU02-15.
  • Monoamine oxidase B (MAOB) gene polymorphisms modulate symptom severity of Autism Spectrum Disorder and platelet serotonin level. Rajamma U, Chakraborti B, Verma D, Karmakar A, Sinha S, Mukhopadhyay K, Mohanakumar KP. 25th ISN-APSN Joint Biennial Meeting in conjunction with ANS at Cairns, Australia. 23rd August-27th August. Poster No. MTU02-17. Monoamine oxidase A gene (MAOA) polymorphisms reveal male-specific effect on specific ASD phenotype. Verma D, Chakraborti B, Karmakar A, Jaiswal P, Sinha S, Mohanakumar KP, Mukhopadhyay K, Rajamma U. 25th ISN-APSN Joint Biennial Meeting in conjunction with ANS at Cairns, Australia. 23rd August-27th August. Poster No. MTU02-22.

 Collaboration with other Organizations

  • CSIR- IICB, Kolkata , India- Active Memorandum of Understanding for basic research
  • University of Calcutta, Kolkata, India- Every year M.Sc students from the departments of Bio chemistry and Neuroscience obtain hands-on training at Manovikas Kendra.



Honors Received

  • Doctor of Philosophy (Ph.D) awarded to Mr. Asem Surindro Singh under the guidance of Dr. Usha Rajamma.
  • Dr. K. Mukhopadhyay, as ethical committee member of the Human Ethics Committee, CSIR-IICB, Kolkata, helped in the preparation of 15 basic research projects.
  • Preeti Jaiswal received travel support from the International Society for Neurosciences to attend the 25th APSN-ISN meeting held at Cairns, Australia.
  • Deepak Verma received travel support from the International Society for Neurosciences to attend the 25th APSN-ISN meeting held at Cairns, Australia.
  • Subhamita Maitra received travel support from the International Society for Neurosciences to attend the 25th APSN-ISN meeting held at Cairns, Australia.
  • Barnali Chakraborti received travel support from the Indian Council of Medical Research to attend the 25th APSN-ISN meeting held at Cairns, Australia.
  • Arpita Dey received travel support from the Science & Engineering Research Board, Ministry of Science & Technology, Govt. of India, to attend the 25th APSN-ISN meeting held at Cairns, Australia.

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