MANOVIKAS BIOMEDICAL RESEARCH AND DIAGNOSTIC CENTRE (MBRDC)

The Centre deals with the genetic basis of neurodevelopmental syndromes, especially those which present with unique opportunities for understanding gene - behaviour relationship and distinct aspects of cognitive / socio - emotional phenotypes. MBRDC is the research wing of Manovikas Kendra, which was inaugurated in August, 2000 by Dr. Manju Sharma, the then Secretary, Department of Biotechnology , Ministry of Science & Technology, Govt. of India. MBRDC has been recognized as a Scientific & Industrial Research Organisation (SIRO) by the Ministry of Science & Technology, Govt. of India. MBRDC has also been recognized as a Genetic Laboratory by the Department of Health & Family Welfare, Govt. of West Bengal. The Centre aims at understanding the disease etiology of subjects suffering from multi-genic disorders like Down syndrome, Autism Spectrum Disorder, Intellectual Disability, Attention Deficit Hyperactivity Disorder, Seizure Disorder, etc. which may eventually help in better rehabilitation.

Dr. Kanchan Mukhopadhyay

Scientist Incharge

Nothing has such power to broaden the mind as the ability to investigate systematically and truly all that comes under thy observation in life (Marcus Aurelius)

CONTRIBUTION OF BASIC RESEARCH TOWARDS THE BENEFIT OF DONORS & PARTICIPANTS

Metabolites and signaling molecules play important regulatory roles in controlling intelligence, behavior, movement, sleep, etc. The ongoing research projects would help in the identification of metabolites and signaling molecules which may be altered in different neurobehavioral disorders, like ADHD, Autism, Down syndrome, and the information generated would be useful for management of various disease associated symptoms through simple dietary supplementation or therapeutic intervention.

SERVICES PROVIDED TO FAMILIES WITH CHALLENGED CHILDREN (50)

  • Report on chromosomal constitution – 1
  • Screening of challenged individuals for FRAXA – 46
  • Autism Diagnostic Observation Schedule executed – 3

MANPOWER DEVELOPMENT

Training of university students from the Departments of Biochemistry and Neuroscience to grow up as researchers in the field of neuroscience.

NATIONAL SUPPORT RECEIVED FOR MANPOWER DEVELOPMENT

Mr. Deepak Verma– CSIR NET Junior Fellow

Ms. Arpita Dey- CSIR-UGC NET Junior Fellow

Ms. Preeti Jaiswal- CSIR Senior Research Fellow

Ms. Barnali Chakraborty – ICMR Senior Research Fellow

Mr. Sudipta Chakraborty- Joined on 20 Feb, 2015 as ICMR project fellow

Ms. Subhamita Maitra- Joined on 18 Feb, 2015 as ICMR project fellow

Ms. Sharmistha Saha – Joined on 19 Feb, 2015 as ICMR research Assistant

Ms. Subhamita Maitra- CSIR Senior Research Fellow



ARTICLES PUBLISHED IN INTERNATIONAL PEER REVIEWED JOURNALS

  • Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males. Chakrabotri B, Verma D, Karmakar A , Jaiswal P , Sanyal A , Paul D , Sinha S , Singh AS, Guhathakurta S, Roychowdhury A , Panda CK, Ghosh S, Mohanakumar KP, Mukhophadhyay K , Usha Rajamma. Progress in Neuro-Psychopharmacology & Biological Psychiatry 56 (2016) In Press.
  • Monoamine Oxidase B gene variants associated with Attention deficit hyperactivity disorder in the Indo-Caucasoid population from West Bengal. Karmakar A, Maitra S, Chakraborti B, Verma D, Sinha S, Mohanakumar KP, Rajamma U, Mukhopadhyay K. BMC Genetics 19:92, 2016.
  • The dopamine receptor D5 may influence age of onset: an exploratory study on Indo-Caucasoid ADHD subjects. Maitra S, Sarkar K, Sinha S, Mukhopadhyay K. Journal of Child Neurology, 2016. doi: 10.1177/0883073816652233.
  • Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders. Jaiswal P, Mohanakumar KP, Rajamma U. Neuroscience and Biobehavioral Reviews 55: 413–431, 2015.

To go through the articles please visit (create a link)

 

 

PRESENTATIONS

  • Positive association of MAOA and VMAT2 with Autism Spectrum Disorder (ASD) in the Indian population. Chakraborti B, Verma D, Sinha S, Mohanakumar KP, Mukhopadhyay K, Rajamma U. 25th ISN-APSN Joint Biennial Meeting in conjunction with ANS at Cairns, Australia. 23rd August-27th August. Poster No. MTU02-02.
  • Gender specific distribution of thyroid stimulating hormone receptor gene variants in subjects with Down syndrome. Dey A, Maity A, Sinha S, Mukhopadhyay K. 25th ISN-APSN Joint Biennial Meeting in rd th conjunction with ANS at Cairns, Australia. 23 August-27 August. Poster No. MTU02-04.
  • A possible modifying role of serotonin transporter gene (SLC6A4) polymorphisms on platelet 5-HT levelsand behavioral phenotypic expression of autism. Jaiswal P, Guhathakurta S, Singh AS, Verma D , Sinha S, Mohanakumar KP, Rajamma U. 25th ISN-APSN Joint Biennial Meeting in conjunction with ANS at Cairns, Australia. 23 August-27 August. Poster No. MTU02-08.
  • A pilot study on the eastern Indian ADHD probands to explore role of CDK 5 in the disease etiology. Maitra S, Chatterjee M, Sinha S, Mukhopadhyay K. 25th ISN-APSN Joint Biennial Meeting in conjunction with ANS at Cairns, Australia. 23rd August-27th August. Poster No. MTU02-15.
  • Monoamine oxidase B (MAOB) gene polymorphisms modulate symptom severity of Autism Spectrum Disorder and platelet serotonin level. Rajamma U, Chakraborti B, Verma D, Karmakar A, Sinha S, Mukhopadhyay K, Mohanakumar KP. 25th ISN-APSN Joint Biennial Meeting in conjunction with ANS at Cairns, Australia. 23rd August-27th August. Poster No. MTU02-17. Monoamine oxidase A gene (MAOA) polymorphisms reveal male-specific effect on specific ASD phenotype. Verma D, Chakraborti B, Karmakar A, Jaiswal P, Sinha S, Mohanakumar KP, Mukhopadhyay K, Rajamma U. 25th ISN-APSN Joint Biennial Meeting in conjunction with ANS at Cairns, Australia. 23rd August-27th August. Poster No. MTU02-22.

COLLABORATION WITH OTHER ORGANIZATIONS

  • CSIR- IICB, Kolkata , India- Active Memorandum of Understanding for basic research
  • University of Calcutta, Kolkata, India- Every year M.Sc students from the departments of Bio chemistry and Neuroscience obtain hands-on training at Manovikas Kendra.



HONORS RECEIVED

  • Doctor of Philosophy (Ph.D) awarded to Mr. Asem Surindro Singh under the guidance of Dr. Usha Rajamma.
  • Dr. K. Mukhopadhyay, as ethical committee member of the Human Ethics Committee, CSIR-IICB, Kolkata, helped in the preparation of 15 basic research projects.
  • Preeti Jaiswal received travel support from the International Society for Neurosciences to attend the 25th APSN-ISN meeting held at Cairns, Australia.
  • Deepak Verma received travel support from the International Society for Neurosciences to attend the 25th APSN-ISN meeting held at Cairns, Australia.
  • Subhamita Maitra received travel support from the International Society for Neurosciences to attend the 25th APSN-ISN meeting held at Cairns, Australia.
  • Barnali Chakraborti received travel support from the Indian Council of Medical Research to attend the 25th APSN-ISN meeting held at Cairns, Australia.
  • Arpita Dey received travel support from the Science & Engineering Research Board, Ministry of Science & Technology, Govt. of India, to attend the 25th APSN-ISN meeting held at Cairns, Australia.

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